Bangabasi Morning College

Research Extension:

To study the molecular and signalling pathways related to cancer by using alternative medicines against differential cancers, alternative drug development and use against differential cancers both in vitro and in vivo models.

Teaching Experience:

Joined as ‘Contractual Whole Time Teacher (CWTT)’ in Dept. of Zoology, Bangabasi Morning College on 19^th August, 2014 till date.

Awards:

1. Selected for Travel Award for basic part in the AMS Award 2015 in “Ethanolic extract of Marsdenia condurango ameliorates benzo[a]pyrene-induced lung cancer of rats”, Journal of Pharmacopuncture, held at New Zealand.
2. Degree of Doctor of Philosophy (Ph.D. degree) in Zoology on 4^th July, 2014 under New Regulation, 2009.
3. Selected for the award of ‘INSPIRE Fellowship’ to the Research Students (220) sponsored by DST. This is recognition to the first rank holders in the Post Graduate Degree in Natural Sciences of any recognized Indian University or Institute for pursuing Doctoral Programme in Science and Technology, New Delhi- 110016, Govt. of India.
4. Received research fellowship for the project entitled as “A comprehensive study on arsenic toxicity and its amelioration by administration of ultra-low doses of homeopathic drugs” from Boiron Laboratory, Lyon, France, under the supervision of Prof. A.R. Khuda-Bukhsh, K.U. for three years (i.e., August, 2010-July, 2013).
5. Qualified Research Eligibility Test (RET) with six months Ph.D. Course work–end examination in 2012 as per the ‘New Regulations’ from the Department of Zoology, University of Kalyani.
6. Enjoyed Senior Research Fellowship from “National Agricultural Innovation Project” (NAIP) entitled “Study on herbal acaricides as means to overcome the development of resistance in ticks to conventional acaricides” at Indian Veterinary Research Institute (IVRI), Eastern Regional Station, Kolkata (22^nd October, 2008-14^th August, 2009).

Professional Membership:

Important Publication:

ORIGINAL PUBLICATIONS IN PEER-REVIEWED INTERNATIONAL JOURNALS

1. Sikdar S, Mukherjee A, Boujedaini N, Khuda-Bukhsh AR, Ethanolic extract of  Condurango (Marsdenia condurango) used in traditional systems of medicine including  homeopathy against cancer can induce DNA damage and apoptosis in non small lung  cancer cells, A549 and H522, in vitro. International Journal of Genuine Traditional Medicine (TANG), 2013, 3 (1), 1-10.
2.  Sikdar S and Khuda-Bukhsh AR, Alternative drug therapies are superior to epidermal growth factor receptor-targeted chemotherapeutic drug responses in non-small cell lung cancer (Review). International Journal of Genuine Traditional Medicine (TANG), 2013, 3 (2), 1-8.
3.  Sikdar S, Mukherjee A, Bishayee K, Paul A , Saha SK, Ghosh S, Khuda-Bukhsh AR. Post-cancer treatment with Condurango 30C shows amelioration of benzo[a]pyrene-induced lung cancer of rats through caspase-3 mediated apoptosis induction. Journal of Pharmacopuncture, 2013, 16(3), 011-022.
4. Sikdar S and Khuda-Bukhsh AR, Post-cancer treatment of Condurango 30C, traditionally used in homeopathy, ameliorates tissue damage and stimulates reactive oxygen species in benzo[a]pyrene-induced lung cancer of rat. Humanitas Traditional Medicine (TANG), 2013, 3(3), e25, 1-8.
5. Sikdar S, Mukherjee A, Ghosh S, Khuda-Bukhsh AR, Condurango glycoside-rich components stimulate DNA damage-induced cell cycle arrest and ROS-mediated caspase-3 dependent apoptosis through inhibition of cell-proliferation in lung cancer, in vitro and in vivo. Environmental Toxicology and Pharmacology, 2014, 37, 300-314.
6. Sikdar S, Saha SK, Khuda-Bukhsh AR, Relative anti-cancer potential of two homeopathic potencies of Condurango (6C and 30C) in non small cell lung carcinoma cells (H460) in vitro: the signaling cascade. Journal of Pharmacopuncture, 17(1), 59-69.
7. Sikdar S, Mukherjee A, Khuda-Bukhsh AR, Ethanolic extract of Marsdenia condurango ameliorates benzo[a]pyrene-induced lung cancer of rats, Journal of Pharmacopuncture, 2014, 17(2), 7-17.
8. Sikdar S and Khuda-Bukhsh AR, Hypermethylation involved in DNA profiles of lung cancer specific tumour suppressor genes and epigenetic modification caused by ultra-highly diluted homeopathic drug, Condurango 30C, in vitro and in vivo, International Journal of High Dilution Research, 2014, 13(47) (Short Communication).
9. Khuda-Bukhsh AR, Sikdar S, Condurango 30C induces epigenetic modification of lung cancer specific tumour suppressor genes via demethylation, Forschende Komplementarmetizin, 2015, DOI: 10.1159/000433485.
10. Sikdar S, Mukherjee A, Khuda-Bukhsh AR, Anti-lung cancer potential of pure esteric-glycoside Condurangogenin A against NSCLC cells in vitro via p21/p53 mediated cell cycle modulation and DNA damage-induced apoptosis, Pharmacognosy magazine, 2015, 11(42), S73-S85.
11. Mukherjee A, Sikdar S, Bishayee K, Paul A, Ghosh S, Boujedaini N, Khuda-Bukhsh AR, Ethanolic extract of Thuja occidentalis blocks proliferation of A549 cells and induces apoptosis in vitro. Journal of Chinese Integrative Medicine, 2012, 10(12), 1451-1459.
12. Chakraborty D, Sikdar S,  Bishayee K, Mukherjee A, Khuda-Bukhsh AR. Helonias dioica extract enhances the anti-diabetic effect of Metformin hydrochloride through increased insulin responsiveness and activation of PI3K/AKT signaling in liver of obese hyperglycemic mice. Chinese Journal of Integrative Medicine, 2013 (article in press).
13. Mukherjee A, Sikdar S, Bishayee K, Khuda-Bukhsh AR, Flavonol isolated from ethanolic leaf extract of Thuja occidentalis arrest cell cycle at G2-M phase and induce ROS independent apoptosis in A549 cells targeting nuclear DNA. Cell Proliferation, 2013, doi: 10.1111/cpr.12079.
14. Mukherjee A, Sikdar S, Khuda-Bukhsh AR, Evaluation of ameliorative potential of isolated flavonol fractions from Thuja occidentalis in lung cancer cells and in Benzo(a)pyrene induced lung toxicity in mice. International Journal of Traditional and Complementary Medicine, 2016, 1(1): 0001-0013
15.  Saha SK, Sikdar S, Mukherjee A, Bhadra K, Boujedaini N, Khuda-Bukhsh AR, Ethanolic extract of the Goldenseal, Hydrastis canadensis, has demonstrable  chemopreventive  effects on HeLa cells in vitro: Drug–DNA interaction with calf thymus DNA as target, Environmental toxicology and pharmacology, 2013, 36, 202–214.
16.  Chakraborty D, Mukherjee A, Sikdar S, Paul A, Ghosh S, Khuda-Bukhsh AR, [6]-Gingerol isolated from ginger attenuates sodium arsenite induced oxidative stress and plays a corrective role in improving insulin signaling in mice. Toxicology Letter, 2012, 210(1), 34-43.
17.  Paul A, Bishayee K, Ghosh S, Mukherjee A, Sikdar S, Chakraborty D, Boujedaini N, Khuda-Bukhsh AR, Chelidonine isolated from ethanolic extract of Chelidonium majus promotes apoptosis in HeLa cells through p38-p53 and PI3K/AKT signalling pathways. Journal of Chinese Integrative Medicine, 2012,10(9):1025-1038.
18.  Ghosh S, Bishayee K, Paul A. Mukherjee A, Sikdar S, Chakraborty D, Boujedaini N, Khuda-Bukhsh AR, Homeopathic mother tincture of Phytolacca  decandra induces apoptosis in skin melanoma cells by activating caspase mediated signaling via reactive oxygen species elevation. Journal of Integrative medicine, Journal of Integrative Medicine, 2013, 11(2),116-124.
19.  Chakraborty D, Ghosh S, Bishayee K, Mukherjee A, Sikdar S, Khuda-Bukh AR, Antihyperglycemic drug  Gymnema sylvestre also shows anticancer potentials in human melanoma A375 cells via reactive oxyzen species generation and mitochondria-dependent caspase pathway, Integrative Cancer Therapies, 2013, DOI: 10.1177/1534735413485419.
20.  Bishayee K, Paul A, Ghosh S, Sikdar S, Mukherjee A, Biswas R, Boujedaini N, Khuda-Bukhsh AR, Condurango-glycoside-A fraction of Gonolobus condurango induces DNA damage associated senescence and apoptosis via ROS-dependent p53 signalling pathway in HeLa cells, Molecular and Cellular Biochemistry, 2013, 382:173-183.
21. Bishayee K, Sikdar S, Khuda-Bukhsh AR, Ultra-highly diluted Gonolobus Condurango extract inhibits histone de-acetylase2 activity in cervix cancer cells in vitro: evidence of epigenetic modification in cell cycle arrest, Journal of Pharmacopuncture, 2013, 16(4), 7-13.
22. Ghosh S, Sikdar S, Mukherjee A, Khuda-Bukhsh AR, Evaluation of chemopreventive potentials of ethanolic extract of Ruta graveolens against A375 skin melanoma cells in vitro and induced skin cancer in mice in vivo., Journal of Integrative Medicine, 2014, doi.org/10.1016/S2095-4964(15)601056-X.
23. Rana T, Sarkar S, Mandal TK, Batabyal S, Datta BK, De S, Sikdar S, Study on the effect of toxicity under highly arsenic prone zone in Nadia district of West Bengal in India, Nature Precedings, 2009, DOI: 10101/npre.2009.2992.1.
24. Rana T, Bera AK, Das S, Pan D, Bandyopadhyay S, Bhattacharya D, De S, Sikdar S, Das SK, Effect of ascorbic acid on blood oxidative stress in experimental chronic arsenicosis in rodents, Food and Chemical Toxicology, 2010, 48: 1072-1077.
25. Bandyopadhyay S, Bera AK, Sikdar S, De S, Das S, Rana T, Pan D, Bandyopadhyay S, Bhattacharya D, Intra-species variability in ITS-1 sequences of Haemonchus contortus isolated from goats in West Bengal, India. Journal of Helminthology, 2011, 85:204-209.
26. Bandyopadhyay S, Bera AK, Sikdar S, De S, Ghosh S, Rana T, Bandyopadhyay S, Dandapat P, Bhattacharya D, Intra-species sequence variability in 28s rRNA gene of Oesophagostomum venulosum isolated from goats of West Bengal, India, Asian Pacific Journal of Tropical Medicine, 2010, 515-518.

ORIGINAL PUBLICATIONS IN PEER-REVIEWED NATIONAL JOURNALS

27. Bandyopadhyay S, Naskar S, Devi P, Bera AK, De S, Pan D, Rana T, Das S, Sikdar S, Bhattacharya D, Multiplex PCR for Identification of Parasitic Eggs of Oesophagostomum spp. Isolated from Sheep and Goat, Proc. Zool. Soc, 2009, 62 (2): 125–129.
28. Kundu K, Yadav M, Pal P, Islam S, Sikdar S, Sarkar S, Parasitic interaction in the gut of Periplaneta americana , Recent Advances in Animal Science Research, Vol. V. 623. 2009.
29. Mukherjee A, Dutta RK, Sharma M, Sengupta M, Das P, Chatterjee R, Sikdar S, Biswas T, Mandal DR, Zooplankton diversity of selected sewage fed and fresh water fishery ponds in East Kolkata wetland, Recent Advances in Animal Science Research, 2009, Vol. V. 626..
30. Dutta RK, Sengupta M, Das P, Sikdar S, Kundu I, Mandal DR, Mukherjee A, Chatterjee R, A study on community composition and species diversity of gastropods of sewage fed & fresh water fishery ponds (bheri) around Kolkata, Recent Advances in Animal Science Research, 2009, Vol. V. 627.

ORIGINAL PUBLICATIONS IN BOOK FORMAT

31. Sikdar S and Sarkar PR, Lung cancer and modern therapeutic approaches: A review. Environmental Impacts on Health: Towards a Better Future, ISBN 978-93-82623-51-1, 2016, 296-316.

Seminars Attended and presented-

5. Attended & presented a poster in the poster session in the State level seminar on “Biodiversity Concerns: In the present Millennium” sponsored by W.B. Biodiversity Board held in Bidhannagar College on 21^st September, 2007.
5. Attended & presented papers (abstract) in the National Seminar “Science since Linnaeus” held in Bidhannagar College on 18^th & 19^th March 2008.
5. Presented a seminar on “Acetylcholinesterase gene in Boophilus microplus and its role in organophosphate resistance” at Division of Parasitology, IVRI, Izatnagar, Bereilly, U.P. on 26^th December, 2008, during the training programme mentioned as follows.
5. “Tick rearing, in vitro testing of acaricides and characterization of acaricides resistant genes” at Entomology Laboratory, Division of Parasitology at IVRI, Izatnagar, Bereilly, U.P. from 28^th November to 27^th December, 2008.
6. Attended National Seminar on plant sciences in the genomic era organized by Department of Botany, University of Kalyani, on 5^th March, 2014.
5. Attended UGC sponsored National Conference on ‘Environmental impacts on health: towards a better future’, organized by Bangabasi Morning College on 27^th and 28^th March, 2015 and delivered lecture on “Lung cancer and modern therapeutic approaches: a review” on 28^th March, 2015.

Research Projects:

Collaborations:

Special Achievements:

LIST OF SEMINARS